Businesses for Sale in St. Louis, MO

This medical practice uses a walk-in model that combines urgent care and primary care services, creating steady daily patient traffic. It may appeal to a buyer seeking a healthcare business with recurring demand, operational efficiency, and room for expansion in the St. Louis area.

This outpatient behavioral health practice offers recurring client demand and multiple potential service expansion paths, which can support growth without starting from zero. It may appeal to a buyer looking for a boutique healthcare business with a trusted reputation in Missouri.

This residential concrete franchise provides a turnkey service business with existing crews, booked work, and reduced overhead from a home-based structure. The recognized brand and financing options may appeal to buyers seeking an entry into the construction trades in Missouri.

This decades-old manufacturing and distribution business in the St. Louis area benefits from deep-rooted client relationships and a strong operational reputation built over many years of consistent performance. The fully equipped facility supports high-volume production and inventory management, providing infrastructure for both current operations and future growth. Owner retirement creates a succession opportunity to acquire a respected platform with clear distribution network expansion potential.

A high-volume grocery store in the St. Louis metro area generating $400,000 in monthly sales and an additional $10,000 per month in gaming income, currently operated under absentee ownership. The store holds a gaming license and benefits from limited local competition, supporting above-average margins in a market with strong consumer demand. The existing absentee ownership model suggests meaningful earnings upside under active management.

This three-unit specialty cookie franchise platform in the greater St. Louis market generated approximately $3.52 million in combined 2025 revenue, supported by a full-time Area Manager and experienced store-level teams across high-growth suburban locations. The business operates additional contracted revenue from a professional sports venue partnership, diversifying income beyond traditional retail foot traffic. Comprehensive operating systems and economies of scale across labor and purchasing create a scalable foundation well-suited for further unit expansion.

This Missouri-based distribution company has served a loyal customer base for over seven decades, generating nearly $1 million in seller discretionary earnings on a sizeable revenue base. The long operating history reflects durable customer relationships and entrenched market positioning within the Midwest region. A business of this tenure and cash flow profile represents a stable platform acquisition for a buyer seeking reliable logistics and distribution operations.

A full-service custom parts manufacturing business in the St. Louis metro area with decades of continuous operation, a seasoned production manager with 30-plus years of tenure, and a 36,000-square-foot facility with real estate included in the purchase price. The retiring founder's exit creates a rare opportunity to acquire a proven industrial manufacturer with an entrenched customer base and day-one revenue. The facility's owned real estate provides both operational stability and a meaningful asset floor for the acquisition.

This mobile environmental testing business serves B2B clients across renovation, demolition, insurance, and disaster recovery sectors in the Midwest, generating demand that is largely regulation-driven and non-discretionary. With a diversified customer base across multiple industries, the business model is insulated from single-sector downturns and operates on a Monday-through-Friday schedule with a small, stable team. The acquisition offers a new owner a systemized operation with built-in recurring demand and meaningful growth potential through expanded client development.

This Missouri remodeling contractor operates across four service divisions — interior and exterior renovation, student housing, multi-family projects, and government work — generating approximately $4M in revenue with over $800K in adjusted EBITDA. The client base includes universities, government agencies, and long-standing referral partners, providing diversified and recurring demand that insulates the business from single-client concentration risk. Strong operational infrastructure and geographic expansion potential into adjacent markets make this an attractive platform for a growth-oriented buyer.

This two-location full-service auto repair business in the St. Louis metro operates with experienced managers in place at each facility, enabling semi-absentee ownership for an investor or multi-unit operator. Both sites benefit from high-visibility locations, strong online ratings, and long-tenured certified technicians, supporting consistent repeat business and community reputation. Optional real estate purchase at each location adds further asset value for a buyer seeking ownership of the underlying property.

This regional trucking company has operated in the St. Louis market for over two decades, building a reputation for reliability with a loyal customer base and well-maintained equipment fleet. An experienced team is in place to ensure continuity through a transition, and the current owner is committed to supporting the handoff process. Pre-approved SBA financing lowers the capital barrier for qualified buyers seeking a proven logistics platform.

A multi-unit baked goods franchise portfolio in the St. Louis metro area ranking among the top-performing locations both regionally and nationally within its franchise system. The portfolio generated over $900K in SDE in 2025 with management in place, supporting a semi-absentee ownership model for a qualified buyer. Top-quartile unit economics and a proven franchise operating system make this a compelling platform acquisition in the food and beverage segment.

A fully staffed psychiatric and mental health practice in the St. Louis metro generating approximately $739K in annual cash flow, supported by an experienced team of therapists, nurse practitioners, and administrative staff. The full operational team in place ensures continuity of care and reduces transition risk for an incoming owner. This type of mental health platform is difficult to build from scratch given licensing requirements, staff credentialing, and patient trust — making an established acquisition an attractive entry strategy.

This St. Louis metro sales and service company has operated for over 20 years, building a loyal B2B and B2C customer base through consistent quality and reliable service from a high-traffic, high-visibility location. The retiring owner is offering a turnkey transition with a business generating over $454,000 in annual cash flow on a $750,000 asking price — a sub-2x multiple that reflects the retirement-motivated sale. Strong organic demand and a proven operating model make this an efficient acquisition for a buyer seeking immediate cash flow.

This St. Louis metro custom home building and remodeling company has operated for over eight decades, earning a premium reputation among high-net-worth clients for exceptional craftsmanship across new construction, additions, and kitchen and bathroom renovations. The business is almost entirely referral and repeat-client driven, with over $15 million in pipeline sales entering the current year. At $1.8 million with nearly $598,000 in annual cash flow, the business trades at a reasonable multiple given its backlog visibility and legacy brand positioning.

This Missouri parking lot maintenance and repair company serves municipalities, apartment complexes, and commercial property managers with seal coating, crack sealing, striping, and signage services in a low-competition local market. Generating $127K in SDE on a $600K asking price, the business includes $375K in asphalt maintenance equipment, making the net business value highly attractive relative to the earnings it produces. Untapped residential and concrete service revenue streams provide clear organic growth opportunities for an ambitious operator.

This St. Louis-area print shop serves a range of business printing needs from standard to specialized output, generating approximately $327K in annual cash flow on a $725K asking price. The business occupies a favorable location and benefits from consistent demand across its commercial client base. The strong earnings-to-price ratio makes this an attractive cash-flowing acquisition for a buyer with operational or print industry experience.

This St. Louis County specialty auto shop has operated under the same ownership for over 25 years, with real estate included in the purchase price and staff retained to support a smooth transition. The long-tenured owner is retiring, providing a motivated seller dynamic and genuine succession opportunity. The combination of owned real property, an operational team, and a well-maintained building makes this a capital-efficient entry into the automotive services sector.

This St. Louis area automotive restoration and repair company specializes in high-quality vehicle repair solutions that eliminate the need for traditional bodywork, generating $316K in annual SDE with minimal overhead. The business maintains strong repeat customer relationships and long-term accounts that provide revenue predictability, and the prime location supports continued walk-in and referral traffic. It is well-suited for an individual buyer or investment group seeking a platform in the specialty automotive services market.

This fast casual restaurant in the St. Louis metro area offers a turnkey operation on nearly three acres with a fully equipped kitchen and updated dining room included in the sale price. A trained staff and loyal customer base are already in place, providing an immediate operational foundation for an experienced restaurateur. The inclusion of real estate in the sale price meaningfully improves the asset coverage and long-term capital position for a buyer.

This franchise-backed air duct cleaning and HVAC restoration company serves both residential and commercial clients in the St. Louis metro area, generating strong recurring revenue from essential indoor air quality services. With a nationally recognized brand and a proven operational model, the business benefits from recession-resistant demand across homes, schools, and commercial properties. The combination of consistent cash flow and a scalable service model makes it attractive for both owner-operators and investors.

This opportunity combines two complementary Midwest trucking and logistics operations with nearly 75 years of collective operating history, a diversified service offering spanning full truckload, flatbed, hazmat, brokerage, expedited, and local hauling, and a combined fleet of 24 tractors and 80 trailers. Together the businesses generate over $1M in annual SDE and are supported by owned industrial real estate, an in-house maintenance shop, and a broad regional customer base across Missouri and surrounding states. At $4.8M asking, this is a compelling platform acquisition for a strategic logistics buyer or owner-operator seeking scale in the Midwest corridor.

This affordable luxury handbag brand holds a strong national wholesale footprint with consistent retailer demand and top-rated platform reviews, offering vegan leather products aligned with current sustainability and ethical fashion trends. The relocatable, asset-light model with outsourced manufacturing keeps overhead minimal while generating $219K in annual SDE. At $550K asking, the 2.5x multiple is attractive for a brand with proven retailer relationships and a differentiated product position in the accessories market.